Yazar "Üçışık, Mehmet Hikmet" için listeleme
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Antileishmanial activity of BNIPdaoct- and BNIPdanon-loaded emulsomes on leishmania infantum parasites
İşlek, Zeynep; Üçışık, Mehmet Hikmet; Keskin, Elif; Onur Sucu, Bilgesu; Gomes-Alves, Ana G.; Tomás, Ana M.; Güzel, Mustafa; Şahin, Fikrettin (Frontiers Media S.A., 2022)Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on ... -
Curcumin- and Piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of Curcumin on HCT116 colorectal cancer model
Bolat, Zeynep Büşra; İşlek, Zeynep; Demir, Bilun Nas; Yılmaz, Elif Nur; Şahin, Fikrettin; Üçışık, Mehmet Hikmet (Frontiers in Bioengineering and Biotechnology, 2020)Combination chemotherapy, administrating two chemotherapeutic agents concurrently, comes into prominence, as the heterogeneity or the level of the disease necessitates a collaborative action. Curcumin, isolated from turmeric, ... -
Cytotoxicity of standardized curcuminoids mixture against epithelial ovarian cancer cell line SKOV-3
Almosa, Heba; Alqriqri, Mihal; Denetiu, Iuliana; Baghdadi, Mohammed Abbas; Alkhaled, Mohammed; Alhosin, Mahmoud; Aldajani, Wejdan A.; Zamzami, Mazin; Üçışık, Mehmet Hikmet (MDPI, 2020)Herbal medicine has been in use for centuries for a wide variety of ailments; however, the efficacy of its therapeutic agents in modern medicine is currently being studied. Curcuminoids are an example of natural agents, ... -
Delivery of curcumin within emulsome nanoparticles enhances the anti-cancer activity in androgen-dependent prostate cancer cell
Bolat, Zeynep Büşra; İşlek, Zeynep; Şahin, Fikrettin; Üçışık, Mehmet Hikmet (Springer, 2023)Background: Curcumin, a dietary polyphenol isolated from turmeric, is a potent phytochemical possessing intrinsic anticancer activities against various cancer types including prostate cancer. However, low water solubility ... -
Development of anti-cancer nanoformulations by incorporation of water-insoluble natural bioactive agents into lipid-based drug delivery systems
Karroum, Reem (İstanbul Medipol Üniversitesi, Fen Bilimleri Enstitüsü, 2022)Broccoli is a well-known and highly consumed vegetable around the world, it falls into the cruciferous category, which is proven to be effective against breast, skin, and prostate cancers. This anti-cancer property stems ... -
Emulsomes meet s-layer proteins: An emerging targeted drug delivery system
Üçışık, Mehmet Hikmet; Sleytr, Uwe Bernd; Schuster, Bernhard (Bentham Science Publishers, 2015)Here, the use of emulsomes as a drug delivery system is reviewed and compared with other similar lipidic nanoformulations. In particular, we look at surface modification of emulsomes using S-layer proteins, which are ... -
Manyetik nanoparçacıkların pankreas kanser hücre hattına özgü DNA nanoparçacıkları ile modifikasyonu yoluyla hücreye hedeflendirilmesi
Keçeloğlu, Gizem (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2020)Kanser türüne özel geliştirilmeye çalışılan kişiselleştirilmiş tıp uygulamaları, aptamer, ligand ve antikor gibi ajanların afiniteye bağlı olarak aktif hedeflemede kullanılmasını içerir. Bu yaklaşım, spesifik bir hücre ... -
Neuroprotective effects of curcumin-loaded emulsomes on laser-induced axotomy modelled primary hippocampal neurons
Yılmaz, Elif Nur (İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2019)As reported by WHO, it has been anticipated that neurodegenerative diseases will be the second cause of death following the cardiovascular diseases by 2040. A polyphenol isolated from the rhizomes of turmeric called curcumin ... -
Novel synthetic approaches for bisnaphthalimidopropyl (BNIP) derivatives as potential anti-parasitic agents for the treatment of leishmaniasis
Keskin, Elif; Üçışık, Mehmet Hikmet; Sucu, Bilgesu Onur; Güzel, Mustafa (MDPI, 2019)Leishmaniasis is a neglected parasitic disease that is widely seen in more than 60 countries worldwide, including Turkey and its subcontinental region. There are several chemotherapy agents for the treatment of leishmaniasis, ...